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. 2003 Feb 10;100(4):1723–1728. doi: 10.1073/pnas.0438033100

Figure 3.

Figure 3

Altered sensorimotor and anxiety levels in WAVE-1 null mice. (A) Rotorod test. The latency to fall during rotarod testing (sec) of wild-type (black squares), heterozygous (gray diamonds), and knockout (white circles) mice is indicated. Mice were tested three times per day over a 7-day period. Daily group averages are represented. Although all groups improved their ability to stay on the rotating rod with training (P < 0.01), WAVE-1 knockout mice fell earlier than heterozygous and wild-type mice (P < 0.01, −/− vs. +/− and +/+, Tukey–Kramer). (B) Inclined-screen test. The frequency of missteping during the inclined-screen test is shown. WAVE-1 knockout mice (−/−) misstepped more often than heterozygous (+/−) and wild-type (+/+) mice (**, P < 0.01 −/− vs. +/− and +/+, Tukey–Kramer). (C) Balance-beam test. Distance moved on a balance beam is shown. WAVE-1 knockout mice (−/−) showed reduced sensorimotor activity as compared with heterozygous (+/−) and wild-type (+/+) mice (**, P < 0.01 −/− vs. +/− and +/+, Tukey–Kramer). (D) Open-field test. The total active time during a 10-min open-field test is presented. WAVE-1 knockout mice (−/−) were significantly less active than heterozygous (+/−) and wild-type (+/+) mice (**, P < 0.01 −/− vs. +/+, and *, P < 0.05 −/− vs. +/−, Tukey–Kramer). (E) Total time in the center and total time spent at the periphery of the open field are indicated for each genotype (marked below each group). WAVE-1 knockout (−/−) mice spent significantly more time in the center and less time in the periphery than heterozygous (+/−) and wild-type (+/+) mice (**, P < 0.01 −/− vs. +/− and +/+, Tukey–Kramer). There was a significant effect of zone in wild-type and heterozygous (P < 0.01) but not in WAVE-1 knockout (P = 0.155) mice. (F) Elevated zero maze. The percentage of time spent in the open areas of the elevated zero maze is shown. WAVE-1 knockout mice (−/−) spent significantly more time in the open areas of the zero maze than heterozygous (+/−) and wild-type (+/+) mice (**, P < 0.01 −/− vs. +/− and +/+, Tukey–Kramer). Error bars represent SEM values.