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. 2003 Feb 6;100(4):1820–1825. doi: 10.1073/pnas.0437846100

Figure 1.

Figure 1

H3-K79 methylation is low at heterochromatic loci. (A) Relative levels of H3-K79 methylation at regions (A–L) at the indicated positions (drawn to scale) with respect to the telomeres and linked genes on chromosome VI. ORF-free regions on chromosomes I and VIII serve as controls and were arbitrarily defined as having H3-K79 levels of 1.0. (B) H3-K79 methylation in wild-type, dot1, and H3-K79 mutant strains at the indicated regions from the telomere of chromosome VI; note difference in scale. (C) H3-K79 methylation at the indicated regions of HMRa, HMRE, and rDNA loci, along with the ORF-free region controls.