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Hypomethylation of H3-K79 at the telomeric and HM, but not rDNA, loci depends on Sir proteins and Sir2 histone deacetylase activity. H3-K79 methylation at the indicated regions (see Fig. 1) in wild-type and sir mutant strains for telomeric (A), HM (regions 1, 3, 4, and 6) (B), and rDNA (C) loci.
