Figure 3.

Amelioration of EAE in FcγRIII-deficient mice. EAE was induced in FcγRIII^−/− (n = 12) and FcγRIII^+/+ (n = 12) with MOG 35–55. FcγRIII^−/− mice have a significantly milder disease compared with FcγRIII^+/+ mice (a, data are shown as mean ± SEM), and they are protected from EAE-related death (b, 0 of 12 in the FcγRIII^−/− mice vs. 4 of 12 in the FcγRIII^+/+). (c) EAE is more remitting in FcγRIII^−/− mice, with 56% (5 of 9) presenting periods of complete remissions compared with 17% (2 of 12) of the wild-type mice.