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Modulation of EAE with H1R antagonist and PAFR antagonist. EAE was induced in SJL/J mice with PLP 139–151. The H1R antagonist pyrilamine (0.6 mg per mouse; n = 8), PAFR antagonist CV6209 (1 μg per mouse; n = 8), or vehicle alone (PBS; n = 7) were given daily i.p. starting on day 2 after the induction of EAE. *, P < 0.05; ***, P < 0.005 by t test for treatment groups vs. naive.
