Figure 3.

Intrinsic interindividual differences in gene expression patterns. (a) Global gene expression was measured in PBMCs from 16 individuals who were each sampled more than once over the course of 1 month. Also included are three patients sampled only once (gray branches). Genes displayed are those with the greatest variation in intrinsic individual differences in expression, i.e., those with intrinsic scores >2 SD from the mean (see text). The expression pattern of the corresponding ≈340 genes is displayed in hierarchical cluster format. Gender is represented by colored branches: blue for male and pink for female. Blue and pink brackets represent samples from the same patient that clustered together. The other colored branches represent repeated samples from single subjects that did not cluster together. (b) DDX17 gene expression (log₂) for up to six samples collected over the course of a month for 20 patients. Data are expressed as the difference from the mean expression level for the entire dataset.