Table 2.
Increase in transcripts in cortex of mice at different ages determined by Northern blot analysis
| MPS III B, mo.
|
MPS I, mo.
|
||||
|---|---|---|---|---|---|
| 1 | 3 | 9 | 1 | 3 | |
| Complement C1q A chain | 2.3 | 2.0 | 1.9 | 2.5 | 2.2 |
| CD68/macrosialin | 1.7 | 2.1 | 2.0 | 2.2 | 2.6 |
| Lysozyme M | 13 | 15 | – | 3.0 | 9.0 |
| Macrophage-specific gene 1 | 3.6 | 1.9 | 2.4 | 3.3 | 3.2 |
| DAP12 | 1.7 | 2.3 | 1.7 | 1.7 | 2.0 |
| Cathepsin S | 2.2 | 2.2 | 1.8 | – | – |
| Glial fibrillary acid protein | 2.0 | 2.9 | 3.5 | – | – |
The numbers represent the fold-increase of the transcripts, determined by Northern blot quantitation as described in Methods.