Figure 7.

Keratinocyte migration in cultured skin explants. (A) Average distance of keratinocyte migration out of skin explants isolated from wild-type (wt), heterozygous (het), or homozygous (homo) K16 ectopic mice was determined. In each instance, the value reported (mean ± SE) was calculated from a pool of 25–30 explants (see MATERIALS AND METHODS). (B–D) Representative examples of skin explants from wild-type (B), heterozygous K16 (C), and homozygous K16 (D) mice after 8 d of culture. The explants (∗) were immunostained for K17 to reveal migrating keratinocytes (K). The keratinocyte migrating front is depicted by a dashed line.