(A and B) Immunostaining for oxidation-specific epitopes expressed as mAb E06-positive arterial sections: A, p66Shc−/− (HFD); B, WT (HFD). (Magnification, ×320.) Arrows indicate the degree of staining. (C) Graph of cumulative immunostaining results. *, P < 0.0001 vs. WT (ND); **, P = 0.056 (not significant) vs. p66Shc−/− (ND); ***, P < 0.0001 vs. WT (HFD).