Skip to main content
. 2006 Jul;7(7):688–693. doi: 10.1038/sj.embor.7400731

Figure 3.

Figure 3

Schematic illustration of the mechanisms by which some commensal bacteria limit pathogen-induced nuclear factor (NF)-κB signalling. Pathogenic bacteria such as Salmonella typhimurium trigger IκB kinase activation, IκBα degradation and nuclear translocation of p50/p65 NF-κB subunits. Some commensal bacteria offset these affects by promoting the nuclear export of activated p65 through associations with peroxisome proliferator-activated receptor (PPAR)γ, thereby terminating promoter activation. Other commensal bacteria inhibit IκBα degradation.