Skip to main content
. 2006 May 18;25(12):2867–2877. doi: 10.1038/sj.emboj.7601156

Figure 5.

Figure 5

Impaired NMDAR-mediated CaMKII signaling in YF/YF mice. (A) Interaction of CaMKII with the WT NR2B, but very little interaction with Y1472FNR2B. NR2B immunoprecipitates (top) and lysates (bottom) were probed with the anti-CaMKII mAb. (B) Impaired glutamate-induced upregulation of CaMKII in YF/YF mice. Stimulation of coronal sections including the LA with glutamate was performed as described in Materials and methods. (C) Quantification of phospho-CaMKII in WT/WT (n=6 from 3 mice) and YF/YF mice (n=6 from 3 mice). *P<0.01, Student's t-test.