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. 2006 Jun 8;25(12):2746–2756. doi: 10.1038/sj.emboj.7601175

Figure 4.

Figure 4

Binding of substrate analogue molecules in the OTMA/TcAChE complex. (A) Overview of the binding sites; (B) binding of OTMA in the CAS; (C) binding of OTMA at the PAS. The CAS residues (Trp84, Glu199 and Phe330), the oxyanion-hole residues (Gly118, Gly119, Ala201) and the catalytic serine (Ser200) and histidine (His440) are shown in (B). The PAS residues (Tyr70, Tyr121 and Trp279) are shown in (C). The Fo–Fc electron density map (contour level 4σ), computed without the atomic coordinates of OTMA, is superimposed on the model.