Table 2.
Definition of the AIRs for the three repressor/operator systems
Protein | DNA | Reference | |
---|---|---|---|
Cro – O1R | |||
Active | K27a,Q29a,S30a,L33a,b | T3c,A4a,c,C5a,A6a,G30cT31a,b,c,T32a,b,c,T33a,G34a,T35a | (50–53) |
Passive | R10,K40,R41,P42 | — | |
Lac – O1 | |||
Active | T5a,b,S16a,Y17b,Q18b,R22b,V30b | T4c,G5a,c,T6a,G7a,A8a,C14c, T15a,c,C16a,A17a,C18a | (54–57) |
Passive | H29,S31 | — | |
Arc – operon | |||
Active | F10a,R13a,S32a | T1c,A2c,T3c,G5c,T6a,A7a,G8a,A9a,A14c,C15c,T16c,C17a,T18a,A19a | (58) |
passive | Q9,N11,R16,D20,R23 | — |
The Arc monomer is composed of two symmetric subunits and only the restraints for one subunit are shown.
aConserved residues derived from the database of homology-derived secondary structure of proteins (HSSP).
bMutagenesis data.
cEthylation interference.