TABLE 3.
1H NMR data of the substrate N-(2-hexylamino-4-phenylimidazol-1-yl)-acetamide and the products A, B, C, and E
| Data for:
|
Proton assignmenta | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Substrate
|
Product A
|
Product B
|
Product C
|
Product E
|
||||||
| δ (ppm) | 3J (Hz) | δ (ppm) | 3J (Hz) | δ (ppm) | 3J (Hz) | δ (ppm) | 3J (Hz) | δ (ppm) | 3J (Hz) | |
| 10.65 | 10.66 | 10.69 | s, 1H, NH, NH—COCH3 | |||||||
| 7.65 | 7.8 | 7.65 | 8.2 | 7.62 | 8.2 | 7.64 | 7.8 | 7.70 | 7.8 | d, 2H, H0, C6H5 |
| 7.30 | 7.8, 7.2 | 7.29 | 8.2, 7.3 | 7.3 | 8.2, 7.3 | 7.29 | 7.8, 7.3 | 7.46 | 7.8, 7.3 | dd, 2H, Hm, C6H5 |
| 7.13 | 7.2 | 7.11 | 7.3 | 6.9 | 7.3 | 7.11 | 7.3 | 7.36 | 7.3 | t, 1H, Hp, C6H5 |
| 7.08 | 7.07 | 7.1 | 7.09 | 7.49 | s, 1H, CH, imidazol | |||||
| 5.5 | 6.01 | s, 2H, NH2 | ||||||||
| 5.83 | 5.7 | 5.84 | 5.8 | 7.88 | 5.98 | 5.8 | 7.85 | 6.1 | t, 1H, NH, NH—CH2 | |
| 3.21 | 3.21 | 3.31 | 3.24 | 3.38 | m, 2H, CH2, CH2—NH | |||||
| 2.22 | 7.3 | 2.28 | 8.2 | 2.29 | 7.4 | t, 2H, CH2, CH2—COOH | ||||
| 1.97 | 1.97 | 1.97 | s, 3H, CH3 | |||||||
| 1.83 | 1.8 | m, 2H, CH2, NH—CH2—CH2—CH2COOH | ||||||||
| 1.54 | 1.59 | m, 2H, CH2, CH2—CH3 | ||||||||
| 1.29 | 1.5, 1.3 | 1.31 | m, 6H, 3xCH2 | |||||||
| 0.87 | 6.6 | 0.88 | 6.7 | t, 3H, CH3, CH3(CH2)5NH | ||||||
a
Underlining reflects assignment of the single NMR signal.