TABLE 1.

Effect of p53 Status on Drug Sensitivity

Drug	Cell Line		p value
	LVCaP*	LNCaP†
	IC50 (nM)
Vincristine	240 ± 43	8.3 ± 0.9	0.001
Doxorubicin	360 ± 28	180 ± 1.0	0.01

^*LNCaP cells transfected with a dominant-negative, temperature-sensitive p53 mutant.

^†Human prostate cancer cells.