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. 2006;117:341–352.

TABLE 1.

Blood Glucose Regulation of Insulin Secretion

Insulin Response to Blood Glucose Insulin Gene Therapy Induced Islet Neogenesis
Glucose-sensing mechanism Liver-type β-cell type
Proinsulin processing Single chain insulin or add sites for furin Yes*
Control mainly posttranscriptional and posttranslational Transcriptional Yes*
Regulated exocytosis: insulin granules No* Yes*
Role of non-β cells No* Yes*
*

“Yes” and “no” refer to the Insulin Response to Blood Glucose pathways depicted in the left column.