TABLE 1.
Insulin Response to Blood Glucose | Insulin Gene Therapy | Induced Islet Neogenesis |
---|---|---|
Glucose-sensing mechanism | Liver-type | β-cell type |
Proinsulin processing | Single chain insulin or add sites for furin | Yes* |
Control mainly posttranscriptional and posttranslational | Transcriptional | Yes* |
Regulated exocytosis: insulin granules | No* | Yes* |
Role of non-β cells | No* | Yes* |
“Yes” and “no” refer to the Insulin Response to Blood Glucose pathways depicted in the left column.