Fig. 2.

Mechanisms by which lytic EBV infection in a small number of tumor cells could contribute to tumor development A. Infectious virus derived from lytically-infected cells can infect new B cells, thus increasing the total number of latently-infected EBV-positive B cells in the host. B. Lytically-infected cells produce the B-cell growth factors, IL-6, cellular IL-10 and viral IL-10, allowing B cells to grow more efficiently. Lytically-infected cells also produce VEGF and thus contribute to angiogenesis in both B-cell and epithelial-cell malignancies.