Figure 6.

Integration of our data into current models, initially based on Brennan and Anderson (2004). Dotted arrows represent potentially pleiotropic signaling that may occur owing to overexpression. Dashed arrows represent hypothetical signaling events that could initially activate JNK signaling during infection or mediate signaling independently of dTAK1, such as during Dif-controlled drosomycin expression. The question mark (?) represents our speculation that other receptor signaling events, such as TNFR activation, also modulate the innate immune response in the Drosophila fat body.