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. 2006 Jun 8;25(13):3191–3202. doi: 10.1038/sj.emboj.7601179

Figure 8.

Figure 8

Models for chn function during photoreceptor cell development. (A) chn is not expressed in photoreceptor cells because of repression by Ebi/SMRTER(SMR)/Su(H), which antagonizes activation by NICD/Su(H). In the absence of Chn, Dl is derepressed and induces cone cell differentiation. Elevation of EGFR signaling causes ectopic expression of Dl (Tsuda et al, 2002), suggesting that EGFR signaling activates Dl expression independently of Ebi/SMR/Su(H) activity (dotted line). (B) At the initiation of the MF, Dl expression seems to be kept at a low level by chn function. Elevation of Dl in the chn mutant might downregulate Notch, which is required for the initiation of the MF (Kumar and Moses, 2001).