Figure 6.

(A) Structure of the native MENT_ΔMloop tetramer in the asymmetric unit. Each monomer is coloured differently; the orange and green monomers form a ‘back to back' dimer (indicated by a dotted oval); the orange molecule forms a loop–sheet linkage (arrow) to the cyan molecule and a loop–sheet linkage to the magenta molecule. hD and hE are labelled. (B) Loop–sheet hydrogen bonds formed by the RCL (brown) of one molecule with the s6A of an adjoining molecule (green). Hydrogen bonds are shown as magenta broken lines. (C) Comparison of native MENT_WT (blue) and MENT_ΔMloop (green) reveals conformational change in the C-terminus (labelled) and s5A/s6A of the A β-sheet of MENT_ΔMloop in response to the interaction with the RCL of a neighbouring molecule (magenta). Note also the different trajectory of the RCL (labelled).