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. 2006 Jun 22;25(13):3000–3011. doi: 10.1038/sj.emboj.7601203

Figure 7.

Figure 7

Models of Fluo-4 AM transport in tumor cells and P. falciparum. (A) Fluo-4 AM passively diffuses through membranes and can be actively extruded by P-gp in tumor cells (left). In parasites, Fluo-4 AM enters by passive diffusion and is converted to the free fluorochrome Fluo-4. Some Pgh-1 variants are capable of pumping both Fluo-4 AM and the membrane impermeable Fluo-4 into the food vacuole. Fluo-4 AM entering the food vacuole is de-esterified by esterases present in this organelle (right) (Krugliak et al, 2003). (B) Predicted topology of Pgh-1. Polymorphisms associated with both increased Fluo-4 AM/Fluo-4 import into the food vacuole and altered drug responses are indicated. NBD, nucleotide-binding domain.