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Chk2 T-loop autophosphorylation sites do not resemble endogenous substrates. Alignment of endogenous Chk2 substrate sequences (CDC25A, CDC25C, BRCA-1, E2F-1, PML) with an optimised substrate sequence (Chk2-TIDE) and T-loop autophosphorylation sites. For each sequence, the residue number of the first amino acid is listed (res). The autophosphorylation sites of Chk2 overlap, as indicated by the underlined regions. The ‘p' column header indicates the phosphorylated amino acid.
