Table 1.
CONTROLS SHAM | UNTREATMENT (mmHg) | EDTA pre-treatment (mmHg) | ||
100 ± 8 | 85 ± 3* | |||
108 ± 11 | 93 ± 2* | |||
Before clamping | End Isc or Isc/R | Before clamping | End Isc or Isc/R | |
Isc | 104 ± 6 | 130 ± 5** | 90 ± 2* | 98 ± 7* |
Isc/R | 105 ± 6 | 115 ± 9 | 90 ± 3* | 88 ± 8* |
EDTA pre-administration (30 min) is able to avoid the increase of MABP induced by kidney Isc. EDTA administration reduces MABP in controls and in sham-operated rats. lsc = ischemia; lsc/R = ischemia/reperfusion.
*p < 0.05 vs. corresponding untreatment; **p < 0.05 vs Isc before clamping