Table 4.
PC21 Low Extreme Genes. Detailed info for (n = 49) extreme genes in PC21 set L21, ordered most extreme first, including common name, description, and associated Gene Ontology terms (provided with the GNF dataset). These extreme genes are shown as blue points in Figure 3.
| PC-21 Value | Name | Description | Function |
| -11.74 | Ckm | creatine kinase, muscle | creatine kinase activity (GO:0004111); transferase activity, transferring phosphorus-containing groups (GO:0016772) |
| -11.61 | ACTA1 | actin, alpha 1, skeletal muscle | motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);structural constituent of cytoskeleton (GO:0005200) |
| -10.27 | MYH7 | myosin, heavy polypeptide 7, cardiac muscle, beta | ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307) |
| -10.01 | TPM1 | tropomyosin 1 (alpha) | actin binding (GO:0003779);muscle development (GO:0007517);regulation of heart rate (GO:0008016);structural constituent of cytoskeleton (GO:0005200);structural constituent of muscle (GO:0008307) |
| -9.10 | MYL1 | myosin, light polypeptide 1, alkali; skeletal, fast | calcium ion binding (GO:0005509);muscle development (GO:0007517);structural constituent of muscle (GO:0008307) |
| -9.10 | TNNC1 | troponin C, slow | calcium ion binding (GO:0005509);muscle development (GO:0007517) |
| -8.92 | PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | glycogen metabolism (GO:0005977);protein phosphatase inhibitor activity (GO:0004864);signal transduction (GO:0007165);type 1 serine/threonine specific protein phosphatase inhibitor activity (GO:0004865) |
| -8.79 | TNNC2 | troponin C2, fast | calcium ion binding (GO:0005509);muscle development (GO:0007517) |
| -8.71 | TNNT1 | troponin T1, skeletal, slow | muscle development (GO:0007517);tropomyosin binding (GO:0005523) |
| -8.70 | KRT14 | keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) | biological_process unknown (GO:0000004);structural constituent of cytoskeleton (GO:0005200);structural constituent of epidermis (GO:0030280) |
| -8.67 | TTID | titin immunoglobulin domain protein (myotilin) | muscle contraction (GO:0006936);protein binding- (GO:0005515);structural constituent of muscle (GO:0008307) |
| -8.49 | HUMMLC2B | myosin light chain 2 | calcium ion binding (GO:0005509);structural constituent of muscle (GO:0008307) |
| -8.35 | TRIM | T-cell receptor interacting molecule | DNA binding (GO:0003677);cellular defense response (GO:0006968);signal transduction (GO:0007165);transmembrane receptor protein tyrosine kinase adaptor protein activity (GO:0005068) |
| -8.20 | TTN | titin | ATP binding (GO:0005524);calmodulin binding (GO:0005516);cation transporter activity (GO:0008324);hematopoietin/interferon-class (D200-domain) cytokine receptor activity (GO:0004896);muscle development (GO:0007517);myosin binding (GO:0017022);protein amino acid phosphorylation (GO:0006468);protein serine/threonine kinase activity (GO:0004674);regulation of actin filament length (GO:0030832);somatic muscle development (GO:0007525);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307);structural molecule activity (GO:0005198);transferase activity (GO:0016740) |
| -7.91 | CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | None |
| -7.66 | MB | myoglobin | electron transporter activity (GO:0005489);globin (GO:0001524);oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810) |
| -7.46 | ENO3 | enolase 3, (beta, muscle) | glycolysis (GO:0006096);lyase activity (GO:0016829);magnesium ion binding (GO:0000287);phosphopyruvate hydratase activity (GO:0004634) |
| -7.32 | NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | ATP binding (GO:0005524);kinase activity (GO:0016301);neurogenesis (GO:0007399);neurotrophin TRKB receptor activity (GO:0005015);neurotrophin binding (GO:0043121);protein amino acid phosphorylation (GO:0006468);receptor activity (GO:0004872);transferase activity (GO:0016740);transmembrane receptor protein tyrosine kinase activity (GO:0004714);transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) |
| -7.28 | MYL2 | myosin, light polypeptide 2, regulatory, cardiac, slow | calcium ion binding (GO:0005509);muscle development (GO:0007517);structural constituent of muscle (GO:0008307) |
| -7.27 | TF | Transferring | ferric iron binding (GO:0008199);iron ion binding (GO:0005506);iron ion homeostasis (GO:0006879);iron ion transport (GO:0006826);transport (GO:0006810) |
| -7.16 | ACSL1 | acyl-CoA synthetase long-chain family member 1 | digestion (GO:0007586);fatty acid metabolism (GO:0006631);ligase activity (GO:0016874);long-chain-fatty-acid-CoA ligase activity (GO:0004467);magnesium ion binding (GO:0000287);metabolism (GO:0008152) |
| -7.10 | MYBPC1 | myosin binding protein C, slow type | actin binding (GO:0003779);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);muscle development (GO:0007517);protein binding (GO:0005515);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307) |
| -7.07 | S100A2 | S100 calcium binding protein A2 | biological_process unknown (GO:0000004);calcium ion binding (GO:0005509) |
| -7.07 | PYGM | phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) | amino acid metabolism (GO:0006520);carbohydrate metabolism (GO:0005975);glycogen metabolism (GO:0005977);glycogen phosphorylase activity (GO:0008184);transferase activity, transferring glycosyl groups (GO:0016757) |
| -6.99 | ACTN2 | actinin, alpha 2 | actin binding (GO:0003779);calcium ion binding (GO:0005509);protein binding (GO:0005515);structural constituent of muscle (GO:0008307) |
| -6.76 | MYBPC2 | myosin binding protein C, fast type | actin binding (GO:0003779);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);muscle development (GO:0007517);protein binding (GO:0005515);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307) |
| -6.71 | UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | binding (GO:0005488);mitochondrial transport (GO:0006839);proton transport (GO:0015992);small molecule transport (GO:0006832);transport (GO:0006810);transporter activity (GO:0005215);uncoupling protein activity (GO:0015302) |
| -6.63 | NEB | nebulin | actin binding (GO:0003779);muscle development (GO:0007517);regulation of actin filament length (GO:0030832);somatic muscle development (GO:0007525);structural constituent of muscle (GO:0008307) |
| -6.60 | IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | carbohydrate metabolism (GO:0005975);glyoxylate cycle (GO:0006097);isocitrate dehydrogenase (NADP+) activity (GO:0004450);main pathways of carbohydrate metabolism (GO:0006092);metabolism (GO:0008152);oxidoreductase activity (GO:0016491);tricarboxylic acid cycle (GO:0006099) |
| -6.47 | CSTA | cystatin A (stefin A) | cysteine protease inhibitor activity (GO:0004869);endopeptidase inhibitor activity (GO:0004866) |
| -6.45 | MYH2 | myosin, heavy polypeptide 2, skeletal muscle, adult | ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);muscle motor activity (GO:0003776);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941) |
| -6.42 | KRT4 | keratin 4 | cytoskeleton organization and biogenesis (GO:0007010);structural constituent of cytoskeleton (GO:0005200);structural molecule activity (GO:0005198) |
| -6.40 | CLIC6 | chloride intracellular channel 6 | chloride transport (GO:0006821);ion transport (GO:0006811);voltage-gated chloride channel activity (GO:0005247) |
| -6.27 | SPRR1A | small proline-rich protein 1A | structural molecule activity (GO:0005198) |
| -6.25 | TNNI2 | troponin I, skeletal, fast | actin binding (GO:0003779);muscle development (GO:0007517) |
| -6.22 | TNNI1 | troponin I, skeletal, slow | actin binding (GO:0003779);muscle development (GO:0007517);tropomyosin binding (GO:0005523) |
| -6.17 | LDB3 | LIM domain binding 3 | electron transport (GO:0006118);electron transporter activity (GO:0005489);protein binding (GO:0005515) |
| -6.14 | CRYAB | crystallin, alpha B | chaperone activity (GO:0003754);muscle contraction (GO:0006936);protein folding (GO:0006457);structural constituent of eye lens (GO:0005212);visual perception (GO:0007601) |
| -6.12 | HFL1 | H factor (complement)-like 1 | plasma protein (GO:0005209) |
| -6.15 | S100A1 | S100 calcium binding protein A1 | calcium ion binding (GO:0005509);cell communication (GO:0007154);intracellular signaling cascade (GO:0007242);neurogenesis (GO:0007399);protein binding (GO:0005515);zinc ion binding (GO:0008270) |
| -6.09 | HSPB8 | heat shock 22 kDa protein 8 | biological_process unknown (GO:0000004);heat shock protein activity (GO:0003773);protein serine/threonine kinase activity (GO:0004674);transferase activity (GO:0016740) |
| -5.93 | PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | None |
| -5.88 | GHR | growth hormone receptor | endocytosis (GO:0006897);growth hormone receptor activity (GO:0004903);growth pattern (GO:0007150);receptor activity (GO:0004872);skeletal development (GO:0001501) |
| -5.85 | ACSL1 | acyl-CoA synthetase long-chain family member 1 | digestion (GO:0007586);fatty acid metabolism (GO:0006631);ligase activity (GO:0016874);long-chain-fatty-acid-CoA ligase activity (GO:0004467);magnesium ion binding (GO:0000287);metabolism (GO:0008152) |
| -5.84 | MGC42493 | hypothetical protein MGC42493 | nucleic acid binding (GO:0003676);zinc ion binding (GO:0008270) |
| -5.73 | SCD | stearoyl-CoA desaturase (delta-9-desaturase) | fatty acid biosynthesis (GO:0006633);iron ion binding (GO:0005506);oxidoreductase activity (GO:0016491);stearoyl-CoA 9-desaturase activity (GO:0004768) |
| -5.67 | hIAN2 | human immune associated nucleotide 2 | GTP binding (GO:0005525) |
| -5.65 | PDE4DIP | phosphodiesterase 4D interacting protein (myomegalin) | None |
| -5.63 | HBA2 | hemoglobin, alpha 2 | oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810) |