Table 6.
GNF human expression principal components having extreme gene sets enriched in GO categories. Each of the GNF human expression PCEG sets, derived using an extremeThresh of 0.00001, was tested for Gene Ontology (GO) statistical enrichment. Terms that were enriched for a particular PC at 1% significance threshold are reported. 26 of the top 42 principal components produced extreme gene lists having significant GO term enrichment.
| PCEG Set | GO Description (p-value) |
| 01 low | GO:0006412 protein biosynthesis (4.51e-07) |
| 03 high | GO:0005201 extracellular matrix structural constituent (1.43e-08) |
| 03 low | GO:0007399 neurogenesis (5.05e-09) GO:0007268 synaptic transmission (9.6e-09) GO:0007417 central nervous system development (1.31e-08) GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (4.85e-07) |
| 04 low | GO:0005201 extracellular matrix structural constituent (5.82e-07) |
| 05 high | GO:0007067 mitosis (3.43e-17) GO:0051301 cell division (4.45e-17) GO:0048015 phosphoinositide-mediated signaling (5.07e-13) GO:0007049 cell cycle (1.79e-09) GO:0006260 DNA replication (5.37e-08) GO:0004674 protein serine/threonine kinase activity (1.09e-07) GO:0005524 ATP binding (1.29e-07) GO:0005634 nucleus (1.93e-07) GO:0006468 protein amino acid phosphorylation (1.01e-06) |
| 05 low | GO:0045012 MHC class II receptor activity (8.59e-08) GO:0006968 cellular defense response (5.07e-07) GO:0006955 immune response (6.9e-07) |
| 07 high | GO:0005201 extracellular matrix structural constituent (3.27e-20) GO:0005578 extracellular matrix (sensu Metazoa) (2.94e-15) GO:0005581 collagen (1.76e-13) GO:0006817 phosphate transport (2.79e-12) GO:0007517 muscle development (8.27e-10) GO:0005518 collagen binding (1.1e-07) GO:0008201 heparin binding (8.6e-07) GO:0007155 cell adhesion (1.55e-06) GO:0005509 calcium ion binding (2.16e-06) |
| 08 high | GO:0007283 spermatogenesis (3.91e-10) |
| 11 low | GO:0042742 defense response to bacteria (1.09e-06) |
| 13 high | GO:0019884 antigen presentation, exogenous antigen (3.23e-16) GO:0019886 antigen processing, exogenous antigen via MHC class II (5.1e-16) GO:0045012 MHC class II receptor activity (5.1e-16) GO:0006955 immune response (1.28e-15) |
| 13 low | GO:0006955 immune response (9.9e-16) GO:0042110 T cell activation (1.15e-10) GO:0007166 cell surface receptor linked signal transduction (1.64e-10) GO:0004888 transmembrane receptor activity (1.25e-09) GO:0006968 cellular defense response (2.05e-07) GO:0019735 antimicrobial humoral response (sensu Vertebrata) (4.81e-07) GO:0005515 protein binding (1.4e-06) |
| 14 low | GO:0005615 extracellular space (4.94e-24) GO:0005319 lipid transporter activity (5.77e-11) GO:0007596 blood coagulation (6.05e-11) GO:0006953 acute-phase response (1.47e-10) GO:0004867 serine-type endopeptidase inhibitor activity (6.14e-10) GO:0004263 chymotrypsin activity (4.83e-09) GO:0004295 trypsin activity (7.86e-09) GO:0006810 transport (1.71e-08) GO:0016042 lipid catabolism (6.48e-08) GO:0005576 extracellular region (8.91e-08) GO:0008201 heparin binding (1.05e-07) GO:0006508 proteolysis and peptidolysis (4e-07) GO:0006869 lipid transport (1.14e-06) |
| 15 high | GO:0005200 structural constituent of cytoskeleton (3.17e-12) GO:0005882 intermediate filament (1.99e-10) GO:0008544 epidermis development (4.44e-10) GO:0007517 muscle development (9.24e-10) |
| 15 low | GO:0008201 heparin binding (1.71e-07) GO:0005201 extracellular matrix structural constituent (3.95e-07) |
| 16 low | GO:0005179 hormone activity (4e-10) GO:0005576 extracellular region (1.51e-07) GO:0007565 pregnancy (1.57e-07) |
| 17 high | GO:0006955 immune response (6.06e-07) |
| 18 high | GO:0005882 intermediate filament (1.47e-11) GO:0005200 structural constituent of cytoskeleton (5.67e-10) GO:0005615 extracellular space (2.74e-08) GO:0008544 epidermis development (1.75e-07) GO:0005319 lipid transporter activity (9.61e-07) GO:0005198 structural molecule activity (1.72e-06) |
| 19 high | GO:0005200 structural constituent of cytoskeleton (2.05e-07) |
| 20 high | GO:0005179 hormone activity (1.88e-08) |
| 21 low | GO:0007517 muscle development (7.01e-27) GO:0008307 structural constituent of muscle (4.15e-23) GO:0003779 actin binding (6.2e-14) GO:0006941 striated muscle contraction (5.69e-10) GO:0005859 muscle myosin (1.99e-08) |
| 22 high | GO:0016042 lipid catabolism (9.41e-08) GO:0004263 chymotrypsin activity (1.94e-06) |
| 23 high | GO:0019825 oxygen binding (1.9e-08) GO:0005344 oxygen transporter activity (2.67e-07) GO:0015671 oxygen transport (3.8e-07) |
| 24 low | GO:0007517 muscle development (8.02e-15) GO:0008307 structural constituent of muscle (2.11e-12) GO:0003779 actin binding (3.61e-09) GO:0005319 lipid transporter actiGO:0005856 cytoskeleton (1e-06) |
| 26 high | GO:0005576 extracellular region (3.7e-10) GO:0005319 lipid transporter activity (2.31e-08) GO:0006869 lipid transport (9.09e-08) |
| 26 low | GO:0008307 structural constituent of muscle (1.19e-08) GO:0005344 oxygen transporter activity (2.67e-07) GO:0015671 oxygen transport (3.8e-07) |
| 29 high | GO:0005615 extracellular space (1.8e-06) |
| 32 low | GO:0005576 extracellular region (3.34e-15) GO:0005615 extracellular space (6.56e-07) GO:0005179 hormone activity (2.15e-06) |
| 35 low | GO:0007585 respiratory gaseous exchange (4e-09) |
| 39 high | GO:0005576 extracellular region (2.35e-07) |
| 40 high | GO:0005179 hormone activity (8.22e-08) GO:0005576 extracellular region (9.39e-07) |
| 42 high | GO:0005179 hormone activity (8.22e-08) GO:0005576 extracellular region (9.39e-07) |