Table 1.
Distribution of cytokine production by glioma infiltrating microglia from 7 representative human glioma patients. Positive intracellular staining was confirmed for all cytokines by either a reporter cell line (A375).
| Pathology | IL-1β | IL-6 | TNF-α |
| GBM | 0% | 0% | 0% |
| GBM | 0% | 0% | 0% |
| GBM | 0% | 0% | 0% |
| GBM | 0% | 0% | 0% |
| GBM | 0% | 0% | 0% |
| AA | 0% | 0% | 0% |
| AA | 0% | 0% | 0% |
| Normal | 0% | 0% | 0% |
| Normal | 0% | 0% | 0% |
| Normal | 0% | 2% | 0% |
| A375 | 58% | 3% | 5% |
Percentages indicate CD11b+CD45+ GIM gated on all CD45+ cells and are adjusted to that of corresponding isotype controls.
Abbreviations: IL, interleukin; TNF, tumor necrosis factor; GBM, glioblastoma multiforme; AA, anaplastic astrocytoma.