Table 1.
Phenotype | High-metastasis phenotype | Low-metastasis phenotype | |||
---|---|---|---|---|---|
Group | Control | Caffeine21 | Caffeine60 | DBA | NZB |
Modification | None | Pharmacological | Pharmacological | Genetic variation | Genetic variation |
Genetic background | FVB/NJ homozygous | FVB/NJ homozygous | FVB/NJ homozygous | DBA/2J × FVB/NJ | NZB/B1NJ × FVB/NJ |
Transgene | PyMT | PyMT | PyMT | PyMT | PyMT |
Treatment | None | Caffeine exposure starting from weaning to 100 days of age | Caffeine exposure starting from 60 days of age to 100 days of age | None | None |