TABLE 2.
Comparative immunogenicity of recombinant products versus that of the HM-175 strain of HAV
| Immunogen | Total antigen (ng) | Anti-HAV titera (no. of mice positive for HAV recognition/total no. of mice) | Neutralization titerb (% HAV neutralization) |
|---|---|---|---|
| 14S i.b. | 200,000 | NTc | 1/4 (66) |
| 14S + 70S VLPd | 0.01 | 1/10,000 | 1/500 (73) |
| 1/50,000 | 1/2,000 (75) | ||
| 1/50,000 (3/5) | 1/2,000 (90) | ||
| 70S + 150S HAV | 1 | 1/100,000 (6/6) | 1/5,000 (90) |
a
Values represent the highest ascitic fluid dilutions positive for HAV recognition.
b
Fractional values represent ascitic fluid dilutions.
c
NT, not tested.
d
VLP, virus-like particles.