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. 2006 Jul 13;116(8):2183–2192. doi: 10.1172/JCI24767

Figure 6. Allergic cytokine production is decreased in allergic aP2-deficient mice.

Figure 6

(A) Detection of IL-5, IL-13, and eotaxin in BAL fluid from nonallergic (n = 10) and allergic (n = 12–15) aP2+/+ or aP2–/– mice. Data represent mean values ± SEM. *P < 0.05; **P < 0.005. (B) IL-5 was measured in culture supernatants from lung-draining lymph node cells restimulated in vitro with OVA or PBS only (Ctrl). Data represent mean ± SEM of 3–4 cultures in triplicate wells with cells pooled from 3–4 mice per culture. #P < 0.0005. (C) Unimpaired T cell proliferation in aP2–/– mice. Splenocytes from OVA/alum-immunized or PBS/alum control mice were stimulated with OVA antigen in vitro and cellular proliferation assayed. Data represent mean ± SEM of triplicate wells with 5 and 2 mice per genotype for OVA/alum and PBS/alum groups, respectively.