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. 2006 Jul 13;116(8):2183–2192. doi: 10.1172/JCI24767

Figure 7. Non-hematopoietic cells are responsible for reduced allergic airway inflammation inaP2–/– mice.

Figure 7

WT or aP2–/– (KO) bone marrow was transferred into irradiated mice to generate KO→WT, WT→KO, or WT→WT (donor→recipient) chimeras, and their responses to allergic airway inflammation assessed. Total (A) and differential (B) cell counts from BAL of bone marrow chimeric mice. Data represent mean values ± SEM for n = 13 KO→WT mice, n = 11 WT→KO mice, and n = 6 WT→WT mice. *P < 0.05 compared with KO→WT mice. (C) Detection of IL-5 and eotaxin in BAL fluid from allergic chimeric mice. Data represent mean ± SEM for n = 13 KO→WT mice and n = 11 WT→KO mice. *P < 0.05; **P < 0.005. (D and E) Detection of IL-5 and IL-13 from culture supernatants of allergic chimeric mouse lung-draining lymph node cells restimulated in vitro with OVA. Data represent mean ± SEM of 3 cultures from cells pooled from 4–5 mice per condition. ND, not detected.