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. 2006 Jul 13;116(8):2280–2289. doi: 10.1172/JCI26283

Figure 5. Activation of PXR inhibits NF-κB signaling in vivo, and NF-κB target gene expression is upregulated in PXR knockout mice.

Figure 5

Ten-week-old male PXR–/– and C57BL6/J (WT) mice (4 per group) were injected intraperitoneally with either the PXR ligand PCN (50 mg/kg) or vehicle control (DMSO) for 3 consecutive days. Liver and intestine tissues were collected, and total RNAs were isolated. Expression of CYP3A11 (A) and multiple NF-κB target genes (B) in WT or PXR–/– mice was determined by QRT-PCR. Statistically significant expression compared with WT control group is marked with asterisks. *P < 0.05; **P < 0.01; and #P < 0.001.