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. 2006 Jul 13;116(8):2173–2182. doi: 10.1172/JCI27303

Figure 7. Pulmonary fibrosis inADA–/– mice treated with CVT-6883.

Figure 7

(A–C) Lung sections from postnatal day 38 mice were stained with an antibody against α-SMA to visualize myofibroblast (brown stain). (A) Lung from an ADA+ mouse treated with vehicle. (B) Lung from an ADA–/– mouse treated with vehicle. (C) Lung from an ADA–/– mouse treated with CVT-6883. (D–F) Lung sections were stained with Masson’s trichrome to visualize collagen deposition (blue stain). (D) Lung from an ADA+ mouse treated with vehicle. (E) Lung from an ADA+ mouse treated with CVT-6883. (F) Lung from an ADA–/– mouse treated with vehicle. (G) Lung from an ADA–/– mouse treated with CVT-6883. Sections are representative of 6 different mice from each treatment. Scale bars: 100 μm. (H) Whole-lung α1-procollagen transcript levels. Data are mean pg transcript/μg RNA ± SEM. (I) Soluble collagen protein levels. Data are mean μg collagen/ml BAL fluid ± SEM. *P ≤ 0.05 versus vehicle-treated ADA+; #P ≤ 0.05 versus vehicle-treated ADA–/–. n = 4 (ADA+), 8 (ADA–/–).