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Cell cycle analysis of HT1376 and MCR cells after exposure to gimatecan (ST1481). Cells were exposed to 0.003 µg/ml (approximately IC50) and 0.03 µg/ml (approximately IC80) of ST1481 for 24 hours and processed for cytofluorimetric analysis after 72-hour incubation in drug-free medium. (A and D) Untreated control. (B and E) Cells treated with 0.003 µg/ml. (C and F) Cells treated with 0.03 µg/ml.
