Table 1.

Effect of Treatment with Liposomal Prednisolone Phosphate, Free Prednisolone Phosphate, or Vehicle on Tumor Size and Tumor Histology. C26 B16.F10

	C26				B16.F10
	Start	End			Start	End
		C	F	L		C	F	L
Tumor size (mm 3)	16	59	48	15	14	163	136	17
Blood vessels	-	+	+	+	-	+	+	+
Hemorrhagic area	-	-	-	-	-	±	±	±
Necrosis	-	-	-	+*	-	±†	±†	+*
High cell density	-	+	+	+	++	++	++	++

Tumor tissue was excised from C26 or B16.F10 tumor-bearing mice at the start of treatment or 3 days after a single intravenous injection with liposomal prednisolonephosphate (L), or free prednisolone phosphate (F) at a dose of 20 mg/kg, or vehicle (C). Tissue slides were evaluated regarding vascularization (CD31 staining), tumorcell density, and occurrence of necrosis and hemorrhagic areas (toluidine bluestaining).

Slides were scored as: (-) (nearly) absent; (+) present; (++) strongly present.

^*Predominantly in tumor core.

^†Infrequently observed without preferential localization.