Table 1.
PSA Downregulates Cancer Gene Expression in PC-3M and LNCaP Cells*.
| Gene ID | Gene Name | PC-3M (Fold) | LNCaP (Fold) |
| Apoptosis | |||
| AA931820 | BCL2-like 1 | 2.25 | NC† |
| pBcl-xl | bcl-xl | 2.31 | NC |
| W45688 | Caspase 6, apoptosis-related cysteine protease | 3.05 | 5.1 |
| AA457705 | Immediate early response 3 | 5.17 | 14.7 |
| H74007 | Serum/glucocorticoid-regulated kinase | 3 | NC |
| Angiogenesis/growth factor | |||
| AA478543 | A kinase (PRKA) anchor protein (gravin) 12 | 3.62 | 48.9 |
| AA446120 | Adrenomedullin | 5.32 | 2.1 |
| AA857163 | Amphiregulin (schwannoma-derived growth factor) | 2.49 | 34.8 |
| AA678160 | CD-55 | 1.87 | 42.7 |
| T62636 | Chemokine (C-X-C motif), receptor 4 (fusin) | 2.99 | 3.4 |
| AA101875 | Chondroitin sulfate proteoglycan 2 (versican) | 2.11 | 4.5 |
| AA598794 | Connective tissue growth factor | 8.66 | 11.5 |
| AA777187 | Cysteine-rich, angiogenic inducer, 61 | 30.54 | 2.7 |
| R09561 | Decay-accelerating factor for complement (CD55) | 1.72 | 58.9 |
| R45640 | Diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) | 2.71 | 2.9 |
| R63623 | Dual-specificity tyrosine phosphorylation-regulated kinase 2 | 2.28 | 9.7 |
| H84481 | EphA2 | 2.17 | 25.7 |
| H13623 | Epidermal growth factor receptor pathway substrate 8 | 3.36 | NC |
| N47214 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | NC | 36.8 |
| H96643 | FOS-like antigen-1 | 5.58 | 21.4 |
| W46900 | GRO1 oncogene (melanoma growth-stimulating activity, α) | 3.06 | NC |
| AA911832 | Homo sapiens cDNA: FLJ22182 fis, clone HRC00953 | 2.05 | 27.5 |
| T62547 | Insulin-like growth factor 2 receptor | 2.1 | NC |
| AA598601 | Insulin-like growth factor-binding protein 3 | 3.77 | NC |
| AA479795 | Interferon-stimulated gene (20 kDa) | 2.27 | NC |
| W47101 | Interleukin 1β | 8.66 | 2.2 |
| N69322 | Matrix metalloproteinase 13 (collagenase 3) | 2.17 | 5.9 |
| AA284669 | Plasminogen activator, urokinase | 12.49 | 131.0 |
| AA454879 | Plasminogen activator, urokinase receptor | 2.86 | 77.4 |
| AA453759 | Sprouty (Drosophila) homolog 2 | 3.57 | 8.1 |
| AA001219 | STAT-induced STAT inhibitor 3 | 4.21 | 2.3 |
| AA464532 | Thrombospondin 1 | 3.35 | NC |
| AA399473 | Tissue factor pathway inhibitor 2 | 8.41 | 6.0 |
| AA233738 | Transforming growth factor, β2 | 3.94 | 12.1 |
| W92764 | Tumor necrosis factor, α-induced protein 6 | 2.17 | 34.2 |
| AA430504 | Ubiquitin carrier protein E2-C | 3.3 | NC |
| AA099568 | Uridine phosphorylase | 5.45 | 12.4 |
| R45059 | Vascular endothelial growth factor | 1.9 | 2.13 |
| AA630120 | Vascular endothelial growth factor B | NC | 2.7 |
| H07899 | Vascular endothelial growth factor C | NC | 26.7 |
| Cell cycle | |||
| AA598974 | Cell division cycle 2, G1 to S and G2 to M | 3.42 | NC |
| AA995402 | Colony-stimulating factor 2 (granulocyte-macrophage) | 4.84 | NC |
| AA079775 | c-src tyrosine kinase | 2.32 | 4.4 |
| AA608568 | Cyclin A2 | 2.34 | NC |
| AA774665 | Cyclin B2 | 2.22 | NC |
| AA444049 | Dual-specificity phosphatase 4 | 4.56 | 5.6 |
| AA460152 | Serum-inducible kinase | 13.18 | NC |
| AA504348 | Topoisomerase (DNA) II α (170 kDa) | 3.32 | 2.1 |
| R80790 | Ubiquitin carrier protein E2-C | 3.44 | NC |
| AA457034 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 2.27 | NC |
| Cell adhesion and cell junction | |||
| AA418564 | Cadherin 12, type 2 (N-cadherin 2) | 2.12 | 5.3 |
| AI336940 | CD6 antigen | 3.08 | NC |
| AA485668 | Integrin, β4 | 1.91 | 80.4 |
| AA490238 | Mitogen-inducible 2 | 3.75 | NC |
| Signal transduction | |||
| AA521232 | HSPC022 protein | 2.12 | 20.6 |
| AA128153 | Interleukin 1 receptor-like 1 | 2.96 | NC |
| AA890663 | p21/Cdc42/Rac1-activated kinase 1 | 2.2 | 17.4 |
| AA447730 | Pim-1 oncogene | 8.35 | 3.6 |
| AI375353 | Serum/glucocorticoid-regulated kinase | 3.46 | 3.8 |
| Transcription | |||
| AA496678 | B-cell CLL/lymphoma 3 | 3.98 | NC |
| W84868 | Cytochrome P450, subfamily IVA, polypeptide 11 | 4 | NC |
| H82442 | Inhibitor of DNA binding 2, helix-loop-helix protein | 2.26 | NC |
| H77597 | Metallothionein 1H | 6.65 | NC |
| AA496628 | Nonmetastatic cells 2, protein (NM23B) expressed | 2.37 | NC |
*
PC-3M and LNCaP cells were treated with 10 µM f-PSA for 48 hours.
†
NC = no significant change.