Figure 6.

Ad-AS/hep treatment inhibits tumor formation in athymic nude (nu/nu) mice. Human malignant melanoma 70W cells were infected with pAd5-Blue control vector (A), Ad-S/hep (B), or Ad-AS/hep (C) and were injected intravenously in 6-week-old female athymic nu/nu mice. At the end of the experimental period, mice were euthanized and examined for tumor formation, as described [25]. Quantification of lung tumor formation and statistical analyses were performed on a number of experimental animals and shown in Table 3.