Table 1.

Therapy of L3.6pl Human Pancreatic Cancer Cells Growing in the Pancreas of Nude Mice.

Treatment	Body Weight (g)		Tumor Incidence	Tumor Weight (g)
	Median	Range		Median	Range
Control	22.1	18.7–26.6	10/10	1.97	0.8–3.78
Gemcitabine	22.6	19.9–25.6	9/9	1.70	0.27–3.13
AEE788	23.8	22.7–26.5	10/10	0.59*	0.19–1.1
AEE788 + gemcitabine	23.1	20.6–25.8	10/10	0.11†	0.02–0.25

L3.6p.l cells (1 x 10⁶) were injected into the pancreas of nude mice. Two weeks later, treatment began and continued for 5 weeks.

The mice were killed on day 36 of treatment (day 50 of the study) and subjected to necropsy.

Body weight, tumor incidence, and weight were determined.

This is one representative experiment of two.

^*P < .05.

^†P < .01 vs control.