Table 2.

IHC Analysis of L3.6pl Human Pancreatic Cancer Cells Growing in the Pancreas of Nude Mice.

Treatment Group	Tumor Cells		Endothelial Cells
	PCNA*	TUNEL*	CD31*	TUNEL+ (%)†
				Mean	Range
Control	488 ± 59	1 ± 1	55 ± 12	0	0–0
Gemcitabine	414 ± 49‡	9 ± 3‡	31 ± 12‡	1	0–3
AEE788	272 ± 52§	15 ± 5§	26 ± 5§	3	0–7
AEE788 + gemcitabine	212 ± 51§	23 ± 6§	16 ± 6§	9	0–16§

^*Mean ± S.D. positive cells per field determined from measurement of 10 random 0.159-mm² fields at x100 magnification.

^†Percentage of CD31/TUNEL⁺ cells in 10 random 0.011-mm² fields at x400 magnification.

^‡P < .01 vs control.

^§P < .001 vs control.