Table 3.

 Mortality from all causes, cardiovascular disease, and cancer by death certification 1996-2002 and age adjusted relative risks (Cox regression), according to treatment allocation at randomisation (intention to treat) in 2686 men and women aged 65-85 years. Values are numbers (percentages) unless stated otherwise

Cause of death*	Vitamin D	Placebo	Age adjusted relative risk (95% CI)	P value†
All	(n=1345)	(n=1341)
All causes	224 (16.7)	247 (18.4)	0.88 (0.74 to 1.06)	0.18
Cardiovascular disease	101 (7.5)	117 (8.7)	0.84 (0.65 to 1.10)	0.20
Ischaemic heart disease	42 (3.1)	49 (3.7)	0.84 (0.56 to 1.27)	0.41
Cerebrovascular disease	28 (2.1)	26 (1.9)	1.04 (0.61 to 1.77)	0.89
Cancer	63 (4.7)	72 (5.4)	0.86 (0.61 to 1.20)	0.37
Colon	7 (0.5)	11 (0.8)	0.62 (0.24 to 1.60)	0.33
Respiratory	10 (0.7)	11 (0.8)	0.89 (0.38 to 2.09)	0.78
Men	(n=1019)	(n=1018)
All causes	199 (19.5)	220 (21.2)	0.88 (0.73 to 1.07)	0.19
Cardiovascular disease	90 (8.8)	106 (10.4)	0.83 (0.62 to 1.10)	0.19
Ischaemic heart disease	38 (3.7)	45 (4.4)	0.83 (0.54 to 1.28)	0.40
Cerebrovascular disease	24 (2.4)	25 (2.5)	0.92 (0.52 to 1.61)	0.77
Cancer	56 (5.5)	59 (5.8)	0.93 (0.64 to 1.34)	0.69
Colon	7 (0.7)	7 (0.7)	0.97 (0.34 to 2.78)	0.96
Respiratory	10 (1.0)	9 (0.9)	1.08 (0.44 to 2.65)	0.87
Women	(n=326)	(n=323)
All causes	25 (7.7)	27 (8.4)	0.91 (0.53 to 1.56)	0.73
Cardiovascular disease	11 (3.4)	11 (3.4)	0.99 (0.43 to 2.30)	0.99
Ischaemic heart disease	4 (1.2)	4 (1.2)	0.99 (0.25 to 3.96)	0.99
Cerebrovascular disease	4 (1.2)	1 (0.3)	3.98 (0.44 to 35.64)	0.22
Cancer	7 (2.1)	13 (4.0)	0.53 (0.21 to 1.33)	0.18
Colon	0	4 (1.2)	NA	0.04
Respiratory	0	2 (0.6)	NA	0.16
Breast	0	0	NA	NA

NA=not applicable. 

^*Cardiovascular disease=ICD-9 codes 390.0-459.9; ischaemic heart disease=410.0-414.0; cerebrovascular disease=430.0-438.0; cancer=140.0-239.9; colon cancer=153.0-154.8; respiratory cancer=160.0-165.9; breast cancer=174.0-175.0; each as underlying cause. 

^†P value refers to difference between treatment groups.