Table 1.
Gene Expression in HPEC Senescence.
| Gene | Accession Number | Fold Change |
| CSPG2 | NM_004385 | 25 |
| PLXDC2 | AY358486 | 21 |
| EST | BG391777 | 19 |
| Wnt5a | NM_003392 | 18 |
| DOC1 | NM_182909 | 17 |
| FBOX32 | AK125888 | 12 |
| OLFML2A | BC054001 | 12 |
| IGF2 | AK074614 | 11 |
| Adlican | AF245505 | 10 |
| COL1A1 | Z74615 | 9.0 |
| MMP2 | AL832088 | 8.6 |
| RKHD3 | AK131424 | 8.4 |
| CKTSF1B1 | AF110137 | 5.5 |
| MFAP2 | BC028033 | 5.2 |
| CXCL14 | NM_004887 | 4.6 |
| P311 | BC011050 | 4.6 |
| MDK | BM473044 | 4.1 |
The expression of 93 genes previously identified to be induced in HPEC senescence by microarray [4] were assayed by QPCR in three additional HPEC cultures undergoing senescence.
Those genes induced greater than four-fold are shown above.
Gene expression was standardized to 18S rRNA expression, and the ratio of expression in senescent cells to the expression in proliferating cultures was determined.