Table 3.
Fold Changes of Specific Genes in PC3 Bone Tumors in SCID-hu Mice Treated with Genistein.
| Gene | Prevention | Intervention |
| Increase | ||
| Apoptosis | ||
| NM 004849.1 Homo sapiens APG5 (autophagy 5, Staphylococcus cerevisiae)-like (APG5L) | 2.6 | NC |
| NM 014456.1 H. sapiens programmed cell death 4 (PDCD4) | 2.3 | NC |
| BF433902 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 2.1 | NC |
| NM 002546.1 tumor necrosis factor receptor superfamily, osteoprotegerin | 2.0 | NC |
| NM 006144.2 H. sapiens granzyme A | 2.6 | NC |
| NM 004402.1 H. sapiens DNA fragmentation factor (caspase-activated DNase) | 2.5 | 2.5 |
| AF001294.1 H. sapiens IPL (IPL) mRNA | 2.1 | NC |
| AF293841.1 H. sapiens apoptosis-related protein (APG5L) | 2.8 | NC |
| NM 022037.1 H. sapiens TIA1 cytotoxic granule-associated RNA-binding protein | 2.1 | NC |
| AF091627.1 H. sapiens CUSP mRNA | 2.1 | NC |
| AB037736.1 H. sapiens mRNA for KIAA1315 protein | 2.1 | 1.7 |
| NM 013229.1 H. sapiens apoptotic protease-activating factor (APAF1) NC | NC | 2.6 |
| Cell cycle arrest, negative regulation of cell proliferation, and transcription | ||
| N23018 C-terminal binding protein 2 | 2.5 | 2.3 |
| NM 003591.1 H. sapiens cullin 2 | 2.0 | NC |
| NM 004585.2 H. sapiens retinoic acid receptor responder 3 | 2.5 | NC |
| NM 020310.1 H. sapiens MAX-binding protein (MNT) | 2.3 | NC |
| BF673013 spectrin SH3 domain-binding protein 1 | 2.1 | NC |
| NM 015895.1 H. sapiens geminin (LOC51053) | 2.0 | 1.7 |
| NM 003451.1 H. sapiens zinc finger protein 177 (ZNF177) | 2.1 | NC |
| BE046521 cut (Drosophila)-like 1 (CCAAT displacement protein) | 2.0 | NC |
| NM 004992.2 H. sapiens methyl CpG-binding protein 2 (MECP2) | NC | 3.7 |
| Decrease | ||
| Signal transduction, chemotaxis | ||
| AW089415 SFRP4 | -2.1 | -1.1 |
| NM 003014.2 H. sapiens SFRP4 | -2.8 | -1.6 |
| BF304996 regulator of G-protein signalling 16 | -2.5 | NC |
| NM 004887.1 H. sapiens small inducible cytokine subfamily B, member 14 | -1.4 | -2.3 |
| NM 002984.1 H. sapiens small inducible cytokine A4 | -2.0 | -1.4 |
| L35594.1 human autotaxin mRNA | -2.1 | -1.1 |
| Regulation of transcription and protein biosynthesis | ||
| NM 014660.1 H. sapiens KIAA0783 gene product (KIAA0783) | -2.5 | -3.7 |
| AF022654.1 H. sapiens homeodomain protein (OG12) mRNA | -2.0 | -2.0 |
| NM 012082.2 H. sapiens friend of GATA2 (FOG2) | -8.0 | NC |
| AK026674.1 H. sapiens cDNA: FLJ23021 fis, similar to HUMSEF21B | -2.0 | -1.4 |
| BC000023.1 H. sapiens, ribosomal protein S19 | -2.3 | -2.1 |
| BF680255 ribosomal protein S11 | -2.3 | -4.0 |
| AW302047 ribosomal protein S10 | -2.1 | -2.6 |
| Oncogenesis | ||
| BC000023.1 H. sapiens, ribosomal protein S19 | -2.3 | -2.1 |
| AW089415 SFRP4 | -2.1 | -1.1 |
| NM 003014.2 H. sapiens | -2.8 | -1.6 |
| BF673699 v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene | -1.3 | -2.0 |