Table 3.
Genes Showing High Copy Gain Common to all Patient Samples Identified by cDNA Array CGH and Hierarchical Clustering, Some of Which are Novel and Previously Unreported in Neuroblastomas.
GenBank accession of clone | UniGene ID | Symbol | Cytoband | Approximate megabase from pter | Function/Evidence |
H19826 | Hs.3618 | HPCAL1 | 2p24 | 9.7 | Calcium-binding protein with similarity to hippocalin, expressed only in the brain. |
R77965, H23930, N45520 | Hs.81412 | LPIN1/KIAA0188 | 2p24 | 11.8 | Gene responsible for fatty liver dystrophy in mice, candidate gene for human lipodystrophy. |
T79037 | - | unknown | 2p24 | 13.6 | Sequence has as very high similarity to genomic clone RP11-516B14 containing NAG gene. |
T65604 | Hs.260855 | NSE1/LOC151354 | 2p24 | 14.15 | Novel member of the H-rev107 protein family. |
R52824 | Hs.25960 | MYCN | 2p24 | 15.45 | Oncogene commonly amplified in neuroblastomas and retinoblastomas. |
H03349 | Hs.241565 | DNMT3A | 2p24 | 24.92 | Gene transcriptional silencing by de novo DNA methylation. |
N68286 | Hs.109391 | unknown | 2p15 | 70.81 | Unknown. |
N95243, AA034934 | Hs.170177 | MEIS1 | 2p15 | 70.83 | Novel homeobox gene. |
Only clones that have been sequence verified are listed.