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Mean external measures of Halobacterium bicluster "quality", as a function of iteration of bicluster optimization. Left: co-expression ("residual," [98]). Center: motif co-occurrence ("Motif log(p-value)"). Right: mutual clustering coefficient (log-p-value [37]) in four different association networks: operons, KEGG [48] metabolic pathways ("met" – see Methods), and Prolinks [23] associations.
