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. Author manuscript; available in PMC: 2006 Jul 13.
Published in final edited form as: Nature. 2005 Jul 21;436(7049):406–409. doi: 10.1038/nature03713

Figure 4.

Figure 4

Rv2869c is required for both Mtb replication and persistence in mice.
  • a and b. Lung bacterial loads plotted (log scale) from mice infected by aerosol with wild type Mtb (black bar), the ΔRv2869c strain (open bar), and the complemented mutant (gray bar) in two separate experiments. The horizontal line indicates the limit of detection of the assay and error bars are SD.
  • c. Gross pathology of infected lungs at 20 weeks from wild type (top), Rv2869c mutant (middle), or complemented mutant (bottom)
  • d. Hematoxylin and eosin-stained lung tissue from C57BL/6 mice infected with wild type (upper panels) and Rv2869c mutant (lower panels) at 6 (left panels) and 22 weeks (right panels) after infection.