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. 2006 Jul 18;3(7):e270. doi: 10.1371/journal.pmed.0030270

Figure 3. Bone Marrow Transplant with MPLW515L-Transduced Bone Marrow Causes a Rapid Myeloproliferative Disease.

Figure 3

(A) Kaplan-Meier survival plot of Balb/C mice transduced with MPLW515L ( n = 9) and MPLWT ( n = 6) showing death of all MPLW515L mice between 17 and 32 days post-BMT compared with MPLWT ( n = 6), which were sacrificed for endpoint analysis without evidence of disease.

(B) Complete blood counts show leukocytosis and thrombocytosis in MPLW515L BMT model compared with MPLWT. There is no difference in hematocrits. Standard deviation is indicated.

(C) Spleen weights of MPLW515L and MPLWT mice shows splenomegaly in MPLW515L mice but not in MPLWT mice with average spleen weight equal to 1,171 mg.

(D) Liver weights of MPLW515L and MPLWT mice shows hepatomegaly in MPLW515L mice but not in MPLWT mice, with average liver weight equal to 2,390 mg (compared with 1,222 mg in MPLWT mice).

(E) Bone marrow shows significantly increased bone marrow fibrosis by reticulin staining at 17 days post-BMT in MPLW515L mice, but not in MPLWT-expressing mice.