Table 1.
Study cohort characteristics
| Characteristic | Value | |
|---|---|---|
| Age (yrs, mean ± SD) | 69.1 ± 6.5 | |
| Female gender | 13 (50%) | |
| History of cognitive impairment | 6 (23%) | |
| Hypertension | 12 (46%) | |
| Diabetes | 1 (4%) | |
| History of stroke | 2 (8%) | |
| History of coronary artery disease | 6 (23%) | |
| ≥1 APOE ɛ2 allele | 9 (35%) | |
| ≥1 APOE ɛ4 allele | 10 (38%) | |
| Scan interval (yrs) | 1.1 (1.0, 2.0) | |
| nWMH volume (mL) | Scan 1 | 4.1 (2.1, 25.1) |
| Scan 2 | 9.7 (1.7, 30.2) | |
| nWMH progression (mL/yr) | 0.5 (0.1, 2.8) | |
| MRI GRE-hemorrhages | Scan 1 | 3 (2, 9) |
| Scan 2 | 4 (2, 14) | |
| New MRI GRE-hemorrhages | 0 (0, 3) |
ICH, intracerebral hemorrhage; APOE, apolipoprotein E; nWMH, MRI white matter hyperintensity volume normalized for head size; GRE, gradient-recalled echo sequence. Continuous variables are median (interquartile range) unless otherwise noted.