Figure 1.

Schematic representation of single and tandem hairpin polyamides designed to target the HPV E2-DNA binding site. The N-methylpyrrole and N-methylimidazole rings are represented by open circles and filled circles, respectively. The flexible β-alanine monomer is represented by a diamond symbol. The γ-turn monomer, R-2,4-diaminobutyric acid, is indicated by a curved line. The dimethylaminopropylamide (Dp) at the C-terminus is represented by a plus sign enclosed within a half-circle. The position of the various flexible linkers (mono-, di-, tetra- and hexaethylene) used in this study is indicated by an open rectangle. The relationship between the polyamide nomenclature and type of linker is indicated in Table 1.