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. 2003 Feb 15;31(4):1282–1291. doi: 10.1093/nar/gkg206

Figure 7.

Figure 7

Model for the inhibition of DNA binding by the major groove-binding HPV-18 E2 homodimer by a reversal of an intrinsic bend in the DNA by a minor groove-binding tandem hairpin polyamide. (A) A hypothetical model is shown for the HPV-18 E2 accentuation of an intrinsic bend in the DNA binding site is based on the enhanced affinity of HPV-16 E2 protein for pre-bent DNA sequences containing adenosine tracts (31) and the increased DNA bending observed in X-ray crystallography studies on BPV-1 E2:DNA co-crystals (33,47). (B) A model for the reversal of the intrinsic bend of the adenosine tract-containing the E2-DNA binding site by the minor groove-binding tandem hairpin polyamide is based on the inhibition of E2 binding experiments shown in Figure 3 and the circular permutation experiment shown in Figure 6.