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. 2003 Mar;5(2):99–109. doi: 10.1016/s1476-5586(03)80001-5

Figure 2.

Figure 2

A synopsis of the crosstalk between AR and the ErbB cascade. This figure provides a brief outline of the interplay of AR and ErbB cascade in promoting PC survival. Growth factor signals augment AR survival signals and enhance AR transactivation through the MAPK/ERK, MEKK/JNKK/c-Jun, and the PI3K/Akt pathways. This enhancement is shown in vitro to occur both in the presence and absence of ligand. Apoptotic responses initiated by stress signals acting through MEKK/JNKK/JNK and the AR can be subverted by activation of the PI3K/Akt pathway downstream of growth factors, thereby allowing PC cell survival.