Figure 1.

Schematic representation of proposed model. Concentrations of platinum are: c_e, extracellular; c_i, intracellular non-DNA bound; c_k, intracellular DNA-bound; $c_{\text{i}}^{\prime }$, released from DNA as a result of DNA repair. Arrows indicate transport or reaction processes. The concentration c_i is much larger than c_k and $c_{\text{i}}^{\prime }$.